Evidence-based Accountability Audits for Cloud Computing

Cloud computing is known for its on-demand service provisioning and has now become mainstream. Many businesses as well as individuals are using cloud services on a daily basis. There is a big variety of services that ranges from the provision of computing resources to services such as productivity suites and social networks. The nature of these services varies heavily in terms of what kind of information is being out-sourced to the cloud provider. Often, that data is sensitive, for instance when PII is being shared by an individual. Also, businesses that move (parts of) their processes to the cloud are actively participating in a major paradigm shift from having data on-premise to transfering data to a third-party provider. However, many new challenges come along with this trend, which are closely tied to the loss of control over data. When moving to the cloud, direct control over geographical storage location, who has access to it and how it is shared and processed is given up. Because of this loss of control, cloud customers have to trust cloud providers that they treat their data in an appropriate and responsible way. Cloud audits can be used to check how data has been processed in the cloud (i.e., by whom, for what purpose) and whether or not this happened in compliance with what has been defined in agreed-upon privacy and data storage, usage and maintenance (i.e., data handling) policies. This way, a cloud customer can regain some of the control he has given up by moving to the cloud. In this thesis, accountability audits are presented as a way to strengthen trust in cloud computing by providing assurance about the processing of data in the cloud according to data handling and privacy policies. In cloud accountability audits, various distributed evidence sources need to be considered. The research presented in this thesis discusses the use of various heterogeous evidence sources on all cloud layers. This way, a complete picture of the actual data handling practices that is based on hard facts can be presented to the cloud consumer. Furthermore, this strengthens transparency of data processing in the cloud, which can lead to improved trust in cloud providers, if they choose to adopt these mechanisms in order to assure their customers that their data is being handled according to their expectations. The system presented in this thesis enables continuous auditing of a cloud provider's adherence to data handling policies in an automated way that shortens audit intervals and that is based on evidence that is produced by cloud subsystems. An important aspect of many cloud offerings is the combination of multiple distinct cloud services that are offered by independent providers. Data is thereby freuqently exchanged between the cloud providers. This also includes trans-border flows of data, where one provider may be required to adhere to more strict data protection requirements than the others. The system presented in this thesis addresses such scenarios by enabling the collection of evidence at providers and evaluating it during audits. Securing evidence quickly becomes a challenge in the system design, when information that is needed for the audit is deemed sensitive or confidential. This means that securing the evidence at-rest as well as in-transit is of utmost importance, in order not to introduce a new liability by building an insecure data heap. This research presents the identification of security and privacy protection requirements alongside proposed solutions that enable the development of an architecture for secure, automated, policy-driven and evidence-based accountability audits

Error Signals from the Brain: 7th Mismatch Negativity Conference

The 7th Mismatch Negativity Conference presents the state of the art in methods, theory, and application (basic and clinical research) of the MMN (and related error signals of the brain). Moreover, there will be two pre-conference workshops: one on the design of MMN studies and the analysis and interpretation of MMN data, and one on the visual MMN (with 20 presentations). There will be more than 40 presentations on hot topics of MMN grouped into thirteen symposia, and about 130 poster presentations. Keynote lectures by Kimmo Alho, Angela D. Friederici, and Israel Nelken will round off the program by covering topics related to and beyond MMN

Digitale Erschließung und Sicherung von aktuellen archäologischen Befunden

Bei Projekten zur Digitalisierung in Geisteswissenschaften ist heute die Realisierung größerer, überregionaler und über das World Wide Web abfragbarer Lösungen erforderlich. Die Beiträge dieses Bandes wurden auf der Tagung des Staatsarchivs Hamburg und des Zentrums "Geisteswissenschaften in der digitalen Welt" an der Universität Hamburg am 10. und 11. April 2006 gehalten. Sie leisten einen interdisziplinären Beitrag zur erforderlichen Standardisierung dieser Angebote, die erst den dringend notwendigen Austausch erleichtern und die gemeinsame Nutzung strukturierter Daten ermöglichen kann.Today, digitization projects in the Humanities require the implementation of larger, supraregional solutions. The contributions in this volume were presented at the conference of the Hamburg State Archives and the Center for the Humanities in the Digital World at the University of Hamburg on April 10 and 11, 2006. They make an interdisciplinary contribution to the required standardisation of corresponding services which can only facilitate the urgently needed exchange of information and make it possible to share structured data

Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer’s disease (AD) Aβ peptides in vivo. This modification confers resistance to proteolysis, rapid aggregation and neurotoxicity and can be prevented by QC inhibitors in vitro and in vivo, as shown in transgenic animal models. However, in mouse brain QC is only expressed by a relatively low proportion of neurons in most neocortical and hippocampal subregions. Here, we demonstrate that QC is highly abundant in subcortical brain nuclei severely affected in AD. In particular, QC is expressed by virtually all urocortin-1-positive, but not by cholinergic neurons of the Edinger–Westphal nucleus, by noradrenergic locus coeruleus and by cholinergic nucleus basalis magnocellularis neurons in mouse brain. In human brain, QC is expressed by both, urocortin-1 and cholinergic Edinger–Westphal neurons and by locus coeruleus and nucleus basalis Meynert neurons. In brains from AD patients, these neuronal populations displayed intraneuronal pE-Aβ immunoreactivity and morphological signs of degeneration as well as extracellular pE-Aβ deposits. Adjacent AD brain structures lacking QC expression and brains from control subjects were devoid of such aggregates. This is the first demonstration of QC expression and pE-Aβ formation in subcortical brain regions affected in AD. Our results may explain the high vulnerability of defined subcortical neuronal populations and their central target areas in AD as a consequence of QC expression and pE-Aβ formation

The auditory cortex of the bat Phyllostomus discolor: Localization and organization of basic response properties

<p>Abstract</p> <p>Background</p> <p>The mammalian auditory cortex can be subdivided into various fields characterized by neurophysiological and neuroarchitectural properties and by connections with different nuclei of the thalamus. Besides the primary auditory cortex, echolocating bats have cortical fields for the processing of temporal and spectral features of the echolocation pulses. This paper reports on location, neuroarchitecture and basic functional organization of the auditory cortex of the microchiropteran bat <it>Phyllostomus discolor </it>(family: Phyllostomidae).</p> <p>Results</p> <p>The auditory cortical area of <it>P. discolor </it>is located at parieto-temporal portions of the neocortex. It covers a rostro-caudal range of about 4800 μm and a medio-lateral distance of about 7000 μm on the flattened cortical surface.</p> <p>The auditory cortices of ten adult <it>P. discolor </it>were electrophysiologically mapped in detail. Responses of 849 units (single neurons and neuronal clusters up to three neurons) to pure tone stimulation were recorded extracellularly. Cortical units were characterized and classified depending on their response properties such as best frequency, auditory threshold, first spike latency, response duration, width and shape of the frequency response area and binaural interactions.</p> <p>Based on neurophysiological and neuroanatomical criteria, the auditory cortex of <it>P. discolor </it>could be subdivided into anterior and posterior ventral fields and anterior and posterior dorsal fields. The representation of response properties within the different auditory cortical fields was analyzed in detail. The two ventral fields were distinguished by their tonotopic organization with opposing frequency gradients. The dorsal cortical fields were not tonotopically organized but contained neurons that were responsive to high frequencies only.</p> <p>Conclusion</p> <p>The auditory cortex of <it>P. discolor </it>resembles the auditory cortex of other phyllostomid bats in size and basic functional organization. The tonotopically organized posterior ventral field might represent the primary auditory cortex and the tonotopically organized anterior ventral field seems to be similar to the anterior auditory field of other mammals. As most energy of the echolocation pulse of <it>P. discolor </it>is contained in the high-frequency range, the non-tonotopically organized high-frequency dorsal region seems to be particularly important for echolocation.</p